Graham S Baldwin Selected Research

big gastrin

7/2017	Progastrin: a potential predictive marker of liver metastasis in colorectal cancer.
5/2015	Identification of binding sites for C-terminal pro-gastrin-releasing peptide (GRP)-derived peptides in renal cell carcinoma: a potential target for future therapy.
1/2015	Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions.
3/2014	Circulating gastrin concentrations in patients at increased risk of developing colorectal carcinoma.
12/2010	The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway.
7/2010	Stimulation of proliferation in the colorectal mucosa by gastrin precursors is blocked by desferrioxamine.
3/2009	Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth.
11/2007	Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.
11/2006	Production, secretion, and biological activity of the C-terminal flanking peptide of human progastrin.
8/2004	PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.

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Graham S Baldwin Research Topics

Disease

28	Neoplasms (Cancer) 01/2019 - 07/2004
26	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 09/2002
10	Pancreatic Neoplasms (Pancreatic Cancer) 01/2019 - 07/2004
10	Hypoxia (Hypoxemia) 10/2018 - 07/2012
10	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 10/2015 - 07/2004
7	Neoplasm Metastasis (Metastasis) 07/2017 - 04/2003
6	Carcinogenesis 06/2017 - 07/2004
5	Adenocarcinoma 01/2020 - 01/2007
5	Prostatic Neoplasms (Prostate Cancer) 02/2018 - 01/2009
4	Carcinoma (Carcinomatosis) 12/2016 - 07/2004
4	Colonic Neoplasms (Colon Cancer) 12/2015 - 01/2006
4	Hemochromatosis (Bronze Diabetes) 05/2011 - 11/2006
3	Kidney Neoplasms (Kidney Cancer) 10/2018 - 05/2015
3	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 12/2015 - 01/2004
3	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2009 - 12/2004
2	Starvation 10/2018 - 01/2008
2	Reperfusion Injury 10/2018 - 01/2017
2	Necrosis 05/2015 - 11/2014
2	Polyps 03/2014 - 03/2009
2	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 03/2014 - 11/2007
2	Iron Overload 05/2011 - 09/2009
2	Multiple Endocrine Neoplasia Type 1 10/2008 - 11/2006
1	Chronic Renal Insufficiency 10/2018
1	Acute Kidney Injury (Acute Renal Failure) 10/2018
1	Fibrosis (Cirrhosis) 01/2017
1	Ischemia 01/2017
1	Renal Cell Carcinoma (Grawitz Tumor) 05/2015
1	Adenomatous Polyps 03/2014

Drug/Important Bio-Agent (IBA)

31	GastrinsIBA 01/2018 - 04/2003
12	big gastrinIBA 07/2017 - 09/2002
12	Glycine (Aminoacetic Acid)FDA LinkGeneric 12/2015 - 12/2004
12	Peptides (Polypeptides)IBA 12/2015 - 09/2002
11	p21-Activated KinasesIBA 01/2019 - 01/2008
10	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2017 - 07/2004
10	Biological ProductsIBA 12/2016 - 12/2004
9	IonsIBA 01/2018 - 11/2006
6	IronIBA 01/2015 - 11/2006
5	ZincIBA 10/2018 - 10/2015
5	Gastrin-Releasing PeptideIBA 05/2015 - 12/2004
4	Gemcitabine FDA Link 01/2019 - 05/2014
4	cobaltous chloride (cobalt(II)chloride)IBA 01/2017 - 07/2012
4	pro-gastrin-releasing peptide (31-98)IBA 05/2015 - 01/2006
4	Messenger RNA (mRNA)IBA 03/2015 - 12/2004
4	MitogensIBA 01/2009 - 09/2004
4	beta CateninIBA 10/2008 - 04/2003
3	Peptide Hormones (Polypeptide Hormones)IBA 01/2018 - 10/2008
3	Biomarkers (Surrogate Marker)IBA 07/2017 - 01/2009
3	glaucarubinoneIBA 12/2016 - 05/2014
3	Phosphotransferases (Kinase)IBA 01/2015 - 04/2012
3	Transferrin (beta 2 Transferrin)IBA 05/2011 - 10/2008
2	BismuthIBA 01/2018 - 01/2004
2	Proteins (Proteins, Gene)FDA Link 01/2017 - 08/2006
2	CobaltIBA 01/2017 - 07/2012
2	LuciferasesIBA 12/2016 - 10/2015
2	LigandsIBA 05/2015 - 08/2004
2	EnzymesIBA 05/2015 - 03/2014
2	Protein Isoforms (Isoforms)IBA 04/2015 - 03/2015
2	CateninsIBA 01/2015 - 04/2012
2	MetalsIBA 01/2015 - 02/2014
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 05/2014 - 09/2010
2	AmidesIBA 03/2014 - 11/2006
2	Cholecystokinin Receptors (Cholecystokinin Receptor)IBA 07/2012 - 01/2007
2	Cholecystokinin B ReceptorIBA 07/2012 - 11/2010
2	AcidsIBA 08/2011 - 08/2006
2	Caspase 3 (Caspase-3)IBA 12/2010 - 01/2008
2	gastrin 17 (G 17)IBA 10/2008 - 12/2002
2	Inositol PhosphatesIBA 01/2006 - 12/2004
1	Indicators and Reagents (Reagents)IBA 01/2019
1	PF 3758309IBA 01/2019
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2019
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 10/2018
1	IndiumIBA 01/2018
1	RutheniumIBA 01/2018
1	CreatinineIBA 01/2017
1	Urea (Carbamide)FDA LinkGeneric 01/2017
1	Calcium Chelating AgentsIBA 12/2016
1	FRAX597IBA 01/2016
1	Transcription Activator-Like Effector NucleasesIBA 10/2015
1	zinc chloride FDA Link 10/2015
1	Peptide Receptors (Peptide Receptor)IBA 05/2015
1	ImmunosorbentsIBA 05/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2015
1	MicroRNAs (MicroRNA)IBA 04/2015
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 04/2015
1	Oxygen (Dioxygen)IBA 03/2015
1	QuassinsIBA 01/2015
1	ThymidineIBA 01/2015
1	IsotopesIBA 01/2015
1	Conditioned Culture MediaIBA 11/2014
1	src-Family KinasesIBA 03/2014

Therapy/Procedure

13	Therapeutics 09/2018 - 08/2006
3	Drug Therapy (Chemotherapy) 12/2016 - 01/2013
2	Immunotherapy 01/2020 - 09/2018
2	Aftercare (After-Treatment) 12/2016 - 03/2006
1	Operative Surgical Procedures 10/2018
1	Nephrectomy 10/2018
1	Kidney Transplantation 10/2018
1	Neoadjuvant Therapy 07/2017
1	Chelation Therapy (Therapy, Chelation) 12/2016
1	Castration 03/2015